Look-up Tables to Link 1991 Population Statistics to the 1998 Local Government Areas

Between 1995 and 1998 the local authority structure and geography of the United Kingdom was substantially revised. The two-tier system of local government was abolished in Wales, Scotland, and in parts of non-metropolitan England, and replaced with a single-tier system. This involved the creation of a new set of local authority area boundaries which in many places cut across those of the old districts. In addition, many of the local authorities unaffected by the reorganisation nonetheless had experienced small - though demographically significant - boundary changes since the last census. By the time the final phase of the reorganisation came into effect on 1st April 1998 the local government map of the United Kingdom was very different from that of April 1991. There is a need therefore to provide demographic and other geographically based data for the new geography for years prior to 1998. This paper aims to fill a part of this requirement by focusing on two important issues. First, it describes a look-up table detailing exactly how the 1998 local government geography relates to 1991 Census areas, and second, it sets out methods for producing 1991 Census data and mid-1991 population estimates (including single year age detail) for the new geography. A selection of the results produced by the described methods is included in tables and population pyramids

Nonlinear structural vibrations by the linear acceleration method

Numerical integration method for calculating dynamic response of nonlinear elastic structure

High-frequency high-voltage high-power DC-to-DC converters

The current and voltage waveshapes associated with the power transitor and the power diode in an example current-or-voltage step-up (buck-boost) converter were analyzed to highlight the problems and possible tradeoffs involved in the design of high voltage high power converters operating at switching frequencies in the range of 100 Khz. Although the fast switching speeds of currently available power diodes and transistors permit converter operation at high switching frequencies, the resulting time rates of changes of current coupled with parasitic inductances in series with the semiconductor switches, produce large repetitive voltage transients across the semiconductor switches, potentially far in excess of the device voltage ratings. The need is established for semiconductor switch protection circuitry to control the peak voltages appearing across the semiconductor switches, as well as to provide the waveshaping action require for a given semiconductor device. The possible tradeoffs, as well as the factors affecting the tradeoffs that must be considered in order to maximize the efficiency of the converters are enumerated

A dc model for power switching transistors suitable for computer-aided design and analysis

A model for bipolar junction power switching transistors whose parameters can be readily obtained by the circuit design engineer, and which can be conveniently incorporated into standard computer-based circuit analysis programs is presented. This formulation results from measurements which may be made with standard laboratory equipment. Measurement procedures, as well as a comparison between actual and computed results, are presented

Analysis of transistor and snubber turn-off dynamics in high-frequency high-voltage high-power converters

Dc to dc converters which operate reliably and efficiently at switching frequencies high enough to effect substantial reductions in the size and weight of converter energy storage elements are studied. A two winding current or voltage stepup (buck boost) dc-to-dc converter power stage submodule designed to operate in the 2.5-kW range, with an input voltage range of 110 to 180 V dc, and an output voltage of 250 V dc is emphasized. In order to assess the limitations of present day component and circuit technologies, a design goal switching frequency of 10 kHz was maintained. The converter design requirements represent a unique combination of high frequency, high voltage, and high power operation. The turn off dynamics of the primary circuit power switching transistor and its associated turn off snubber circuitry are investigated

Keypad mobile phones are associated with a significant increased risk of microbial contamination compared to touch screen phones

The use of mobile phones in the clinical environment by healthcare workers has become widespread. Despite evidence that these devices can harbour pathogenic micro-organisms there is little guidance on how to reduce contamination. Recently touchscreen phones with a single flat surface have been introduced. We hypothesise that bacterial contamination of phones used in hospitals will be lower on touchscreen devices compared to keypad devices. Sixty seven mobile phones belonging to health care workers were sampled. The median colony count for touchscreen phones and keypad devices was 0·09 colony forming units (cfu)/cm2 (interquartile range (IQR) 0.05–0·14) and 0·77 cfu/cm2 (IQR range 0·45–3.52) respectively. Colony counts were significantly higher on the keypad phones (Fisher’s exact test p<0.001). Multivariate analysis showed the type of phone (keypad vs. touch screen) was associated with increased colony counts (F-statistic 14.13: p<0.001). Overall, nine (13%) phones grew either meticillin resistant Staphylococcus aureus or vancomycin resistant enterococci. Eight (24%) keypad phones were contaminated with these organisms compared with one touch screen phone (3%). Our data indicate that touchscreen mobile phones are less contaminated than their keypad counterparts, and they are less likely to harbour pathogenic bacteria in the clinical setting

ClassTR: Classifying Within-Host Heterogeneity Based on Tandem Repeats with Application to Mycobacterium tuberculosis Infections.

Genomic tools have revealed genetically diverse pathogens within some hosts. Within-host pathogen diversity, which we refer to as "complex infection", is increasingly recognized as a determinant of treatment outcome for infections like tuberculosis. Complex infection arises through two mechanisms: within-host mutation (which results in clonal heterogeneity) and reinfection (which results in mixed infections). Estimates of the frequency of within-host mutation and reinfection in populations are critical for understanding the natural history of disease. These estimates influence projections of disease trends and effects of interventions. The genotyping technique MLVA (multiple loci variable-number tandem repeats analysis) can identify complex infections, but the current method to distinguish clonal heterogeneity from mixed infections is based on a rather simple rule. Here we describe ClassTR, a method which leverages MLVA information from isolates collected in a population to distinguish mixed infections from clonal heterogeneity. We formulate the resolution of complex infections into their constituent strains as an optimization problem, and show its NP-completeness. We solve it efficiently by using mixed integer linear programming and graph decomposition. Once the complex infections are resolved into their constituent strains, ClassTR probabilistically classifies isolates as clonally heterogeneous or mixed by using a model of tandem repeat evolution. We first compare ClassTR with the standard rule-based classification on 100 simulated datasets. ClassTR outperforms the standard method, improving classification accuracy from 48% to 80%. We then apply ClassTR to a sample of 436 strains collected from tuberculosis patients in a South African community, of which 92 had complex infections. We find that ClassTR assigns an alternate classification to 18 of the 92 complex infections, suggesting important differences in practice. By explicitly modeling tandem repeat evolution, ClassTR helps to improve our understanding of the mechanisms driving within-host diversity of pathogens like Mycobacterium tuberculosis

Evidence for bimodal orbital separations of white dwarf-red dwarf binary stars

We present the results of a radial velocity survey of 20 white dwarf plus M dwarf binaries selected as a follow up to a \textit{Hubble Space Telescope} study that aimed to spatially resolve suspected binaries. Our candidates are taken from the list of targets that were spatially unresolved with \textit{Hubble}. We have determined the orbital periods for 16 of these compact binary candidates. The period distribution ranges from 0.14 to 9.16\,d and peaks near 0.6\,d. The original sample therefore contains two sets of binaries, wide orbits ($\approx100-1000$\,au) and close orbits ($\lesssim1-10$\,au), with no systems found in the $\approx10-100$\,au range. This observational evidence confirms the bimodal distribution predicted by population models and is also similar to results obtained in previous studies. We find no binary periods in the months to years range, supporting the post common envelope evolution scenario. One of our targets, WD\,1504+546, was discovered to be an eclipsing binary with a period of 0.93\,d

Assessing digital preservation frameworks: the approach of the SHAMAN project

How can we deliver infrastructure capable of supporting the preservation of digital objects, as well as the services that can be applied to those digital objects, in ways that future unknown systems will understand? A critical problem in developing systems is the process of validating whether the delivered solution effectively reflects the validated requirements. This is a challenge also for the EU-funded SHAMAN project, which aims to develop an integrated preservation framework using grid-technologies for distributed networks of digital preservation systems, for managing the storage, access, presentation, and manipulation of digital objects over time. Recognising this, the project team ensured that alongside the user requirements an assessment framework was developed. This paper presents the assessment of the SHAMAN demonstrators for the memory institution, industrial design and engineering and eScience domains, from the point of view of user’s needs and fitness for purpose. An innovative synergistic use of TRAC criteria, DRAMBORA risk registry and mitigation strategies, iRODS rules and information system models requirements has been designed, with the underlying goal to define associated policies, rules and state information, and make them wherever possible machine-encodable and enforceable. The described assessment framework can be valuable not only for the implementers of this project preservation framework, but for the wider digital preservation community, because it provides a holistic approach to assessing and validating the preservation of digital libraries, digital repositories and data centres